Targeting and Cellular Trafficking of Magnetic Nanoparticles for Prostate Cancer Imaging

Imaging Cellular Proliferation in Prostate Cancer with Positron Emission Tomography

Prostate cancer remains a major public health problem worldwide. Imaging plays an important role in the assessment of disease at all its clinical phases, including staging, restaging after definitive therapy, evaluation of therapy response, and prognostication. Positron emission tomography with a number of biologically targeted radiotracers has been demonstrated to have potential diagnostic and...

Cell targeting and imaging using magnetic nanoparticles

GLP-1R–Targeting Magnetic Nanoparticles for Pancreatic Islet Imaging

Noninvasive assessment of pancreatic β-cell mass would tremendously aid in managing type 1 diabetes (T1D). Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide-based nanoparticle probe targeting glucagon-like peptide 1 receptor (GLP-1R), which is highly expressed on the surface of pancreatic β-cells. In vitro studies in βTC-6, the β-cell line, showed specific accumulatio...

Targeting Cancer Gene Therapy with Magnetic Nanoparticles

Recent advances in cancer genomics have opened up unlimited potential for treating cancer by directly targeting culprit genes. However, novel delivery methods are needed in order for this potential to be translated into clinically viable treatments for patients. Magnetic nanoparticle technology offers the potential to achieve selective and efficient delivery of therapeutic genes by using extern...

Molecular Nuclear Imaging for Targeting and Trafficking

Noninvasive molecular targeting in living subjects is highly demanded for efficient delivery of drugs, genes, or radionuclides in the course of diagnosing or treating diseases. Nuclear medicine has been used for decades to evaluate in vivo biochemistry using organor cell-specific radiopharmaceuticals such as iodine for thyroid follicular cells. Recent progress in molecular biology provides tool...